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The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China

[ Vol. 19 , Issue. 2 ]

Author(s):

Yin Yueqi, Zhou Ying, Lu Jing, Guo Hongxiong, Chen Jianshuang, Xuan Yan, Cheng Hao, Yuan Defu, Hu Haiyang, Xu Xiaoqin, Wang Bei* and Fu Gengfeng*   Pages 188 - 194 ( 7 )

Abstract:


Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years.

Objective: This study aimed to report on novel HIV-1 recombinants.

Methods: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1.

Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world.

Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.

Keywords:

HIV-1, recombinant, MSM, near full-length genome, URF, CRF.

Affiliation:

Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Wuxi Xinwu District Center for Disease Control and Prevention, Wuxi 214028, Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009

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