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Metabolic and Cardiovascular Complications of Highly Active Antiretroviral Therapy for HIV Infection

[ Vol. 4 , Issue. 1 ]

Author(s):

Giuseppe Barbaro   Pages 79 - 85 ( 7 )

Abstract:


Highly active antiretroviral therapy (HAART) regimens, especially those including protease inhibitors have been shown to cause, in a high proportion of HIV-infected patients, a metabolic syndrome (lipodystrophy/lipoatrophy, dyslipidemia, type 2 diabetes mellitus, insulin resistance) that may be associated with an increased risk of cardiovascular disease. A careful stratification of the cardiovascular risk of HIVinfected patients under HAART is needed according to the most recent clinical guidelines.

Keywords:

Human immunodeficiency virus, highly active antiretroviral therapy, nucleoside reverse transcriptase inhibitors, protease inhibitors, metabolic syndome, cardiovascular disease

Affiliation:

Viale Anicio Gallo 63,00174 Rome, Italy.



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