Xingguo Miao, Hui Ye, Shoufeng Yang and Feifei Su* Pages 1 - 4 ( 4 )
Background: Concurrence of talaromycosis, an infection caused by the opportunistic fungal pathogen Talaromyces marneffei and Kaposi sarcoma, a common vascular tumor, is a rare but severe medical condition in patients infected with the human immunodeficiency virus (HIV). Despite poor outcomes, the clinical characteristics and management strategies for HIV-infected patients with comorbid Kaposi sarcoma and talaromycosis have not been well documented.
Case presentation: A 33-year-old, HIV-positive male patient presented to the Department of Infectious Diseases at Wenzhou Central Hospital with cough, sputum expectoration, hemoptysis, rashes on the feet and violaceous plaques in the oral cavity. Chest computed tomography (CT) showed bilateral nodules, patchy shadows and lymphadenectasis. Skin biopsy and histopathological examination indicated Kaposi sarcoma. T. marneffei was isolated from blood cultures and suggested talaromycosis. The patient’s overall conditions significantly improved following initiation of combination antiretroviral therapy (cART) and chemotherapy for Kaposi sarcoma and antifungal treatment for talaromycosis.
Conclusions: Severe medical conditions such as Kaposi sarcoma and talaromycosis may coexist in HIV-infected patients and pose an increased risk of mortality. Etiological diagnosis and treatment are the key to successful management of HIVinfected patients with these concurrent conditions.
HIV infection, talaromycosis, Kaposi sarcoma, concurrence, management, cART.
Department of Infectious Diseases, Wenzhou Central Hospital, Zhejiang, 32500, Department of Infectious Diseases, Wenzhou Central Hospital, Zhejiang, 32500, Department of Infectious Diseases, Wenzhou Central Hospital, Zhejiang, 32500, Department of Infectious Diseases, Wenzhou Central Hospital, Zhejiang, 32500