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Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital

[ Vol. 18 , Issue. 6 ]

Author(s):

T. Shintani*, T. Iwata, M. Okada, M. Nakaoka, N. Yamasaki, T. Fujii and H. Shiba   Pages 475 - 479 ( 5 )

Abstract:


Background: Dental professionals have so many opportunities to use injection needles and sharp instruments during dental treatment that they face an increased risk of needlestick injuries. This retrospective study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with anti-retroviral agents after being potentially exposed to HIV at the dental departments of Hiroshima University Hospital.

Objective: This study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with antiretroviral agents after being potentially exposed to HIV at dental departments of Hiroshima University Hospital.

Methods: Data on the clinical status of HIV-infected source patients and information on HIV-exposed dental professionals from 2007 to 2018 were collected.

Results: Five dentists with an average experience of 5.6 years (1-15 years) were exposed. The averaged CD4-positive cell number and HIV-RNA load were 1176 (768-1898) /μl and less than 20 copies/ml, respectively, in all the patients. Two of the five HIV exposed dentists received PEP. Three months after the exposures, all of their results were negative in HIV antibody/antigen tests.

Conclusion: ; These data might support the concept of “undetectable equals untransmittable”, although HIV exposure in this study was not through sexual transmission.

Keywords:

HIV, U=U, occupational exposures, post-exposure prophylaxis, needlestick injury, dental treatment.

Affiliation:

Center of Oral Clinical Examination, Hiroshima University Hospital, Department of Periodontal Medicine, Graduate School of Biomedical & Sciences, Hiroshima University, Division of Dental Hygiene, Department of Clinical Practice and Support, Hiroshima University Hospital, Division of Dental Hygiene, Department of Clinical Practice and Support, Hiroshima University Hospital, Division of Blood Transfusion, Hiroshima University Hospital; 5AIDS Care Unit, Hiroshima University Hospital, Division of Blood Transfusion, Hiroshima University Hospital; 5AIDS Care Unit, Hiroshima University Hospital, Center of Oral Clinical Examination, Hiroshima University Hospital

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