Daniel Vargas-Pacherrez*, Carlos Brites, Helma P. Cotrim and Carla Daltro Pages 324 - 331 ( 8 )
Introduction: The prevalence of arterial hypertension (AH) in HIV-patients is highly variable and its association with antiretroviral therapy (ART) is controversial.Objective: To estimate the prevalence of AH and associated factors in HIV-patients on ART. Methods: This cross-sectional study was conducted in HIV-patients attended in a referral center in Salvador, Brazil. We evaluated clinical, socio-demographic and anthropometric data. Student's ttests or Mann-Whitney's and Pearson's chi-square tests were used to compare the groups. Values of p <0.05 were considered significant. The variables that presented a value of p <0.20 were included in a logistic regression model. Results: We evaluated 196 patients (60.7% male) with a mean age of 46.8 ± 11.7 years and a mean body mass index of 24.9 ± 5.3 kg / m2. The median elapsed time since HIV diagnosis and ART use was 11.8 (4.4 - 18.1) and 7.2 (2.7 - 15.3) years, respectively. The prevalence of AH was 41.8%. For individuals > 50 years old, there was a significant association between the increased abdominal circumference and AH and patients ≤ 50 years old presented significant association between AH and overweight, increased abdominal circumference and number of previous ART regimens. After multivariate analysis, age [OR:1.085; 95% CI 1,039 – 1,133], overweight [OR: 4.205; 95% CI 1,841 – 9,606], family history of AH [OR: 2.938; 95% CI 1,253 – 6.885], increased abdominal circumference [OR: 2.774; 95% CI 1.116 – 6.897] and life-time number of ART regimens used [OR: 3.842; 95% CI 1.307 – 11.299] remained associated with AH. Conclusion: AH was highly prevalent and was associated not only with classical risk factors for arterial hypertension, but also with specific ART regimens.
HIV, acquired immunodeficiency syndrome, highly active antiretroviral therapy, prevalence, essential hypertension, cardiovascular diseases.
Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Bahia, Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Bahia, Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Bahia, Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Bahia