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Relation of Steatosis to Neurocognitive Function in People Living with HIV

Author(s):

Daniela Maric*, Snežana Brkić , Vojislava Bugarski Ignjatović , Željka Nikolašević , Dalibor Ilić , Miloš Vujanović , Zorka Drvendžija and Biljana Srdić Galić   Pages 1 - 9 ( 9 )

Abstract:


Background: In HIV negative population metabolic syndrome and steatosis are related to poorer neurocognitive (NC) performance. We set out to find if similar relation exists in people living with HIV (PLWH).

Methods: we included male PLWH aged 20-65, with undetectable viral load for at least 6 months. Data on levels of education, anthropometric measurements, CD4 levels, ART, markers of metabolic syndrome, smoking and concurrent treatment were collected from database. Concentrations of TNF-α and IL-6 were measured. An ultrasound was used to establish the presence of steatosis, visceral fat thickness and carotid intima media thickness. An extensive NC assessment was done by an experienced neuropsychologist. Cognitive domains were defined as executive functions, divergent reasoning, visuo-constructional abilities, delayed recall and working memory and learning and were measured using a battery of 12 tests.

Results: 88 PLWH were included (mean age 39,9 years), 51% on PIs, 46% on NNRTI; 20,4% had metabolic syndrome, 42% patients had steatosis. Weak but statistically significant negative correlations were found between the presence of metabolic syndrome, steatosis and VFT and cognitive domains (divergent reasoning, delayed recall and working memory). Poorer perfomrance in the domains of divergent reasoning and in the working memory were found in participants with steatosis (p=0,048 and 0,033 respectivly).

Conclusion: Although the sample size was relatively small our results show consistent correlations between the observed neurocognitive variables and metabolic parameters. As central obesity is one of the contributors to NCI it would be one of the modifiable factors to prevent further neurocognitive decline.

Keywords:

HIV, steatosis, neurocognition, metabolic syndrome, central obesity

Affiliation:

Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Department of Psychology, Faculty of Medicine, University of Novi Sad, Novi Sad, Department of Psychology, Faculty of Medicine, University of Novi Sad, Novi Sad, Clinic for Radiology, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Department of Anathomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Department of Anathomy, Faculty of Medicine, University of Novi Sad, Novi Sad



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