Submit Manuscript  

Article Details


Genotypic Methods for HIV Drug Resistance Monitoring: The Opportunities and Challenges Faced by China

[ Vol. 17 , Issue. 4 ]

Author(s):

Lulu Zuo, Ke Peng, Yihong Hu* and Qinggang Xu*   Pages 225 - 239 ( 15 )

Abstract:


AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of “90-90-90” to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase the emergence and spreading of HIV drug resistance and current HIV drug resistance test (DRT) assays in China are seriously lagging behind, hindering to achieve virological suppression. Therefore, recommending an appropriate HIV DRT method is critical for HIV routine surveillance and prevention in China. In this review, we summarized the current existing HIV drug resistance genotypic testing methods around the world and discussed the advantages and disadvantages of these methods.

Keywords:

HIV/AIDS, drug resistance test, genotypic methods, antiretroviral therapy, oligonucleotide ligation assay, HIV routine surveillance.

Affiliation:

Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212002, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Pathogen Discovery & Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; Shanghai 200031, Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212002

Graphical Abstract:



Read Full-Text article