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Prediction of CD4+ Cells Counts in HIV/AIDS Patients based on Sets and Probability Theories

[ Vol. 16 , Issue. 6 ]

Author(s):

Javier Rodriguez*, Signed Prieto, Catalina Correa, Martha Melo, Dario Dominguez, Nancy Olarte, Daniela Suárez, Laura Aragón, Fernando Torres and Fernando Santacruz   Pages 416 - 424 ( 9 )

Abstract:


Background: Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes.

Objective: To improve the methodology probabilities prediction in 5000-9000 leukocytes ranges.

Method: from sets A, B, C and D defined in a previous study, and based on CD4+ prediction established on the total number of leukocytes and lymphocytes, induction was performed using data from 10 patients with HIV, redefining the sets A and C that describe the lymphocytes behavior relative to leukocytes. Subsequently, we evaluated with previous research prediction probabilities parameters from a sample of 100 patients, calculating the belonging probability to each sample and organized in predetermined ranges leukocytes, of each of the sets defined, their unions and intersections. Then the same procedure was performed with the new sets and the probability values obtained with the refined method were compared with respect to previously defined, by measures of sensitivity (SENS) and Negative Predictive Value (NPV) for each range.

Results: probabilities with values greater than 0.83 were found in five of the nine ranges inside the new sets. The probability for the set A∪C increased from 0.06 to 0.18 which means increases between 0.06 and 0.09 for the intersection (A∪C) ∩ (B∪D), making evident the prediction improvement with new sets defined.

Conclusion: The results show that the new defined sets achieved a higher percentage of effectiveness to predict the CD4+ value cells, which represents a useful tool that can be proposed as a substitute for clinical values obtained by the flow cytometry.

Keywords:

CD4, blood count, lymphocytes, HIV/AIDS, prediction, probability.

Affiliation:

Insight Group Director, Focusing Area and Special Internship "Physical and Mathematical Theories Applied to Medicine", Nueva Granada Military University - Clinica del Country Research Center, Bogota, Insight Group Researcher, Nueva Granada Military University, Clinica del Country Research Center, Bogota, Insight Group Researcher, Teacher of Major and Special "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Clinica del Country Research Center, Bogota, Magister in Educational Institutions Management, FRACUMNG Group Researcher, Basic and Applied Sciences Faculty, Nueva Granada Military University, Bogota, Magister in Economics, FRACUMNG Research Group Director, Basic and Applied Sciences Faculty, Nueva Granada Military University, Bogota, Esp in Information Technologies Applied to Education, GI-iTEC Group Researcher, Engineering Faculty, Nueva Granada Military University, Bogota, Special Internship and Focusing Area "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Bogota, Special Internship and Focusing Area "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Bogota, Special Internship and Focusing Area "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Bogota, Special Internship and Focusing Area "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Bogota

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